Tumor Suppressor p53 Slides on DNA with Low Friction and High Stability

The p53 protein, a transcription factor of key importance in tumorigenesis, is suggested to diffuse one-dimensionally along DNA via its C-terminal domain, a process that is proposed to regulate gene activation both positively and negatively. There has been no direct observation of p53 moving along D...

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Bibliografische gegevens
Hoofdauteurs: Tafvizi, Anahita, Huang, Fang, Leith, Jason S., Fersht, Alan R., Mirny, Leonid A., van Oijen, Antoine M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Biophysical Society 2008
Onderwerpen:
Biophysical Letters
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2426630/
https://ncbi.nlm.nih.gov/pubmed/18424488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.108.134122
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