The Tabby phenotype is caused by mutation in a mouse homologue of the EDA gene that reveals novel mouse and human exons and encodes a protein (ectodysplasin-A) with collagenous domains

Mouse Tabby (Ta) and X chromosome-linked human EDA share the features of hypoplastic hair, teeth, and eccrine sweat glands. We have cloned the Ta gene and find it to be homologous to the EDA gene. The gene is altered in two Ta alleles with a point mutation or a deletion. The gene is expressed in dev...

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Detalhes bibliográficos
Main Authors: Srivastava, Anand K., Pispa, Johanna, Hartung, Andrew J., Du, Yangzhu, Ezer, Sini, Jenks, Ted, Shimada, Tokihiko, Pekkanen, Maija, Mikkola, Marja L., Ko, Minoru S. H., Thesleff, Irma, Kere, Juha, Schlessinger, David
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences of the USA 1997
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC24264/
https://ncbi.nlm.nih.gov/pubmed/9371801
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