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Crystal structure of trioxacarcin A covalently bound to DNA
We report a crystal structure that shows an antibiotic that extracts a nucleobase from a DNA molecule ‘caught in the act’ after forming a covalent bond but before departing with the base. The structure of trioxacarcin A covalently bound to double-stranded d(AACCGGTT) was determined to 1.78 Å resolut...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2008
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2425490/ https://ncbi.nlm.nih.gov/pubmed/18453630 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn245 |
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