Loss of TGFβ Signaling Destabilizes Homeostasis and Promotes Squamous Cell Carcinomas in Stratified Epithelia

Although TGFβ is a potent inhibitor of proliferation, epithelia lacking the essential receptor (TβRII) for TGFβ signaling display normal tissue homeostasis. By studying asymptomatic TβRII-deficient stratified epithelia, we show that tissue homeostasis is maintained by balancing hyperproliferation wi...

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Autori principali: Guasch, Géraldine, Schober, Markus, Pasolli, H. Amalia, Conn, Emily Belmont, Polak, Lisa, Fuchs, Elaine
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2424201/
https://ncbi.nlm.nih.gov/pubmed/17936557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2007.08.020
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