Neonatal bone marrow transplantation of ADA-deficient SCID mice results in immunologic reconstitution despite low levels of engraftment and an absence of selective donor T lymphoid expansion

Adenosine deaminase (ADA)–deficient severe combined immune deficiency (SCID) may be treated by allogeneic hematopoietic stem cell transplantation without prior cytoreductive conditioning, although the mechanism of immune reconstitution is unclear. We studied this process in a murine gene knockout mo...

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Detalhes bibliográficos
Main Authors: Carbonaro, Denise A., Jin, Xiangyang, Cotoi, Daniel, Mi, Tiejuan, Yu, Xiao-Jin, Skelton, Dianne C., Dorey, Frederick, Kellems, Rodney E., Blackburn, Michael R., Kohn, Donald B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2008
Assuntos:
Transplantation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2424166/
https://ncbi.nlm.nih.gov/pubmed/18356486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-08-103663
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