Identification of Pou5f1, Sox2, and Nanog downstream target genes with statistical confidence by applying a novel algorithm to time course microarray and genome-wide chromatin immunoprecipitation data

BACKGROUND: Target genes of a transcription factor (TF) Pou5f1 (Oct3/4 or Oct4), which is essential for pluripotency maintenance and self-renewal of embryonic stem (ES) cells, have previously been identified based on their response to Pou5f1 manipulation and occurrence of Chromatin-immunoprecipitati...

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Bibliographic Details
Main Authors: Sharov, Alexei A, Masui, Shinji, Sharova, Lioudmila V, Piao, Yulan, Aiba, Kazuhiro, Matoba, Ryo, Xin, Li, Niwa, Hitoshi, Ko, Minoru SH
Format: Artigo
Language:Inglês
Published: BioMed Central 2008
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2424064/
https://ncbi.nlm.nih.gov/pubmed/18522731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-9-269
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