Binding of sFRP-3 to EGF in the Extra-Cellular Space Affects Proliferation, Differentiation and Morphogenetic Events Regulated by the Two Molecules

BACKGROUND: sFRP-3 is a soluble antagonist of Wnts, widely expressed in developing embryos. The Wnt gene family comprises cysteine-rich secreted ligands that regulate cell proliferation, differentiation, organogenesis and oncogenesis of different organisms ranging from worms to mammals. In the canon...

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Main Authors: Scardigli, Raffaella, Gargioli, Cesare, Tosoni, Daniela, Borello, Ugo, Sampaolesi, Maurilio, Sciorati, Clara, Cannata, Stefano, Clementi, Emilio, Brunelli, Silvia, Cossu, Giulio
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2008
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2424011/
https://ncbi.nlm.nih.gov/pubmed/18560570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0002471
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