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NF-κB-dependent Transcriptional Activation in Lung Carcinoma Cells by Farnesol Involves p65/RelA(Ser(276)) Phosphorylation via the MEK-MSK1 Signaling Pathway
In this study, we demonstrate that treatment of human lung adenocarcinoma H460 cells with farnesol induces the expression of a number of immune response and inflammatory genes, including IL-6, CXCL3, IL-1α, and COX-2. This response was dependent on the activation of the NF-κB signaling pathway. Farn...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2423266/ https://ncbi.nlm.nih.gov/pubmed/18424438 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800945200 |
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