Targeted Disruption of the Basic Krüppel-Like Factor Gene (Klf3) Reveals a Role in Adipogenesis

Krüppel-like factors (KLFs) recognize CACCC and GC-rich sequences in gene regulatory elements. Here, we describe the disruption of the murine basic Krüppel-like factor gene (Bklf or Klf3). Klf3 knockout mice have less white adipose tissue, and their fat pads contain smaller and fewer cells. Adipocyt...

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Hauptverfasser: Sue, Nancy, Jack, Briony H. A., Eaton, Sally A., Pearson, Richard C. M., Funnell, Alister P. W., Turner, Jeremy, Czolij, Robert, Denyer, Gareth, Bao, Shisan, Molero-Navajas, Juan Carlos, Perkins, Andrew, Fujiwara, Yuko, Orkin, Stuart H., Bell-Anderson, Kim, Crossley, Merlin
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2008
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2423134/
https://ncbi.nlm.nih.gov/pubmed/18391014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01942-07
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