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Respiratory Francisella tularensis Live Vaccine Strain Infection Induces Th17 Cells and Prostaglandin E(2), Which Inhibits Generation of Gamma Interferon-Positive T Cells

Two key routes of Francisella tularensis infection are through the skin and airway. We wished to understand how the route of inoculation influenced the primary acute adaptive immune response. We show that an intranasal inoculation of the F. tularensis live vaccine strain (LVS) with a 1,000-fold-smal...

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Detalhes bibliográficos
Main Authors: Woolard, Matthew D., Hensley, Lucinda L., Kawula, Thomas H., Frelinger, Jeffrey A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2423094/
https://ncbi.nlm.nih.gov/pubmed/18391003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01412-07
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