Dominant Role of Paraoxonases in Inactivation of the Pseudomonas aeruginosa Quorum-Sensing Signal N-(3-Oxododecanoyl)-l-Homoserine Lactone

The pathogenic bacterium Pseudomonas aeruginosa causes serious infections in immunocompromised patients. N-(3-Oxododecanoyl)-l-homoserine lactone (3OC12-HSL) is a key component of P. aeruginosa's quorum-sensing system and regulates the expression of many virulence factors. 3OC12-HSL was previou...

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Autors principals: Teiber, John F., Horke, Sven, Haines, Donovan C., Chowdhary, Puneet K., Xiao, Junhui, Kramer, Gerald L., Haley, Robert W., Draganov, Dragomir I.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2008
Matèries:
Molecular Pathogenesis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2423076/
https://ncbi.nlm.nih.gov/pubmed/18347034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01606-07
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