In Vitro Selection and Characterization of Ceftobiprole-Resistant Methicillin-Resistant Staphylococcus aureus

Methicillin-resistant Staphylococcus aureus (MRSA) is resistant to β-lactam antibiotics because it expresses penicillin-binding protein 2a (PBP2a), a low-affinity penicillin-binding protein. An investigational broad-spectrum cephalosporin, ceftobiprole (BPR), binds PBP2a with high affinity and is ac...

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Hlavní autoři: Banerjee, Ritu, Gretes, Michael, Basuino, Li, Strynadka, Natalie, Chambers, Henry F.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2008
Témata:
Mechanisms of Resistance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2415812/
https://ncbi.nlm.nih.gov/pubmed/18378703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01403-07
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