The fitness of defective interfering murine coronavirus DI-a and its derivatives is decreased by nonsense and frameshift mutations.

The genome of the defective interfering (DI) mouse hepatitis virus DI-a carries a large open reading frame (ORF) consisting of ORF1a, ORF1b, and nucleocapsid sequences. To test whether this fusion ORF is important for DI virus replication, we constructed derivatives of the DI-a genome in which the r...

Полное описание

Библиографические подробности

Опубликовано в::	J Virol
Главные авторы:	de Groot, R J, van der Most, R G, Spaan, W J
Формат:	Artigo
Язык:	Inglês
Опубликовано:	American Society for Microbiology (ASM) 1992
Предметы:	Research Article
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC241466/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1326650/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.66.10.5898-5905.1992
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