Spectrum and characterisation of BRCA1 and BRCA2 deleterious mutations in high-risk Czech patients with breast and/or ovarian cancer

BACKGROUND: The incidence of breast cancer has doubled over the past 20 years in the Czech Republic. Hereditary factors may be a cause of young onset, bilateral breast or ovarian cancer, and familial accumulation of the disease. BRCA1 and BRCA2 mutations account for an important fraction of heredita...

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Main Authors: Machackova, Eva, Foretova, Lenka, Lukesova, Mirka, Vasickova, Petra, Navratilova, Marie, Coene, Ilse, Pavlu, Hana, Kosinova, Veronika, Kuklova, Jitka, Claes, Kathleen
Format: Artigo
Language:Inglês
Published: BioMed Central 2008
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2413254/
https://ncbi.nlm.nih.gov/pubmed/18489799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-8-140
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