A monoclonal antibody to CD4 domain 2 blocks soluble CD4-induced conformational changes in the envelope glycoproteins of human immunodeficiency virus type 1 (HIV-1) and HIV-1 infection of CD4+ cells.

The murine monoclonal antibody (MAb) 5A8, which is reactive with domain 2 of CD4, blocks human immunodeficiency virus type 1 (HIV-1) infection and syncytium formation of CD4+ cells (L. C. Burkly, D. Olson, R. Shapiro, G. Winkler, J. J. Rosa, D. W. Thomas, C. Williams, and P. Chisholm, J. Immunol., i...

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Bibliografische gegevens
Gepubliceerd in:J Virol
Hoofdauteurs: Moore, J P, Sattentau, Q J, Klasse, P J, Burkly, L C
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology (ASM) 1992
Onderwerpen:
Research Article
Online toegang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC241306/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1378510/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.66.8.4784-4793.1992
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