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Divergent roles of endothelial NF-κB in multiple organ injury and bacterial clearance in mouse models of sepsis
To define the roles of endothelial-intrinsic nuclear factor κB (NF-κB) activity in host defense and multiple organ injury in response to sepsis, we generated double transgenic (TG) mice (EC-rtTA/I-κBαmt) that conditionally overexpress a degradation-resistant form of the NF-κB inhibitor I-κBα (I-κBαm...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2413029/ https://ncbi.nlm.nih.gov/pubmed/18474628 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20071393 |
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