The CHEK2(*)1100delC mutation has no major contribution in oesophageal carcinogenesis

In response to DNA damage, the cell cycle checkpoint kinase 2 (CHEK2) may phosphorylate p53, Cdc25A and Cdc25C, and regulate BRCA1 function, leading to cell cycle arrest and DNA repair. The truncating germline mutation CHEK2(*)1100delC abrogates kinase activity and confers low-penetrance susceptibil...

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Main Authors: Koppert, L B, Schutte, M, Abbou, M, Tilanus, H W, Dinjens, W N M
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2004
Teme:
Genetics and Genomics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2410163/
https://ncbi.nlm.nih.gov/pubmed/14970869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6601551
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