Phase I/II study of DHA–paclitaxel in combination with carboplatin in patients with advanced malignant solid tumours

DHA–paclitaxel is a conjugate of paclitaxel and the fatty acid, docosahexaenoic acid. Preclinical studies have demonstrated increased activity, relative to paclitaxel, with the potential for an improved therapeutic ratio. We conducted a phase I study to determine the maximum tolerated doses of DHA–p...

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Detalhes bibliográficos
Main Authors: Harries, M, O'Donnell, A, Scurr, M, Reade, S, Cole, C, Judson, I, Greystoke, A, Twelves, C, Kaye, S
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2004
Assuntos:
Clinical
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2410023/
https://ncbi.nlm.nih.gov/pubmed/15494716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602196
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