Faecal tumour M2 pyruvate kinase: a new, sensitive screening tool for colorectal cancer

Proliferating cells, especially tumour cells, express a special isoenzyme of pyruvate kinase, termed M2-PK, which can occur in a tetrameric form with a high affinity to its substrate, phosphoenolpyruvate (PEP), and in a dimeric form with a low PEP affinity. In tumour cells, the dimeric form is usual...

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Bibliografiske detaljer
Main Authors: Hardt, P D, Mazurek, S, Toepler, M, Schlierbach, P, Bretzel, R G, Eigenbrodt, E, Kloer, H U
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2004
Fag:
Molecular and Cellular Pathology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2409989/
https://ncbi.nlm.nih.gov/pubmed/15266315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602033
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