Low-dose interferon-γ-producing human neuroblastoma cells show reduced proliferation and delayed tumorigenicity

Interferon-γ (IFN-γ) directs T helper-1 cell differentiation and mediates antitumour effects in preclinical models. However, high-dose IFN-γ is toxic in vivo, and IFN-γ-transfected neuroblastoma (NB) cells secreting high amounts of the cytokine may be lost due to cell apoptosis or differentiation. T...

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Main Authors: Airoldi, I, Meazza, R, Croce, M, Di Carlo, E, Piazza, T, Cocco, C, D'Antuono, T, Pistoia, V, Ferrini, S, Corrias, M V
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2004
Fag:
Molecular and Cellular Pathology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2409504/
https://ncbi.nlm.nih.gov/pubmed/15150552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6601842
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