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Late resistance to imatinib therapy in a metastatic gastrointestinal stromal tumour is associated with a second KIT mutation

Currently, there are no data on the secondary resistance of gastrointestinal stromal tumours to imatinib. Here, we report a case of metastatic gastrointestinal stromal tumour that relapsed during imatinib therapy. Mutation analysis showed that the imatinib-resistant liver tumour contained two c-kit...

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Detalhes bibliográficos
Main Authors: Wakai, T, Kanda, T, Hirota, S, Ohashi, A, Shirai, Y, Hatakeyama, K
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2409485/
https://ncbi.nlm.nih.gov/pubmed/15150562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6601819
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