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Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome

To study the pathogenesis of central nervous system abnormalities in Down syndrome (DS), we have analyzed a new genetic model of DS, the partial trisomy 16 (Ts65Dn) mouse. Ts65Dn mice have an extra copy of the distal aspect of mouse chromosome 16, a segment homologous to human chromosome 21 that con...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Holtzman, David M., Santucci, Daniela, Kilbridge, Joshua, Chua-Couzens, Jane, Fontana, David J., Daniels, Scott E., Johnson, Randolph M., Chen, Karen, Sun, Yuling, Carlson, Elaine, Alleva, Enrico, Epstein, Charles J., Mobley, William C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1996
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24093/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8917591/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.23.13333
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