Transformation-defective mutants of polyomavirus middle T antigen associate with phosphatidylinositol 3-kinase (PI 3-kinase) but are unable to maintain wild-type levels of PI 3-kinase products in intact cells.

Middle T antigen (MT) of polyomavirus causes transformation by associating with a number of cellular proteins. The association with and activation of two such proteins, phosphatidylinositol 3-kinase (PI 3-kinase) and pp60c-src, appears to be necessary for transformation by MT. The tyrosine kinase ac...

Szczegółowa specyfikacja

Zapisane w:
Opis bibliograficzny
Wydane w:J Virol
Główni autorzy: Ling, L E, Druker, B J, Cantley, L C, Roberts, T M
Format: Artigo
Język:Inglês
Wydane: American Society for Microbiology (ASM) 1992
Hasła przedmiotowe:
Research Article
Dostęp online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC240916/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1371171/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.66.3.1702-1708.1992
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