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Chlorpyrifos and Chlorpyrifos-Oxon Inhibit Axonal Growth by Interfering with the Morphogenic Activity of Acetylcholinesterase

A primary role of acetylcholinesterase (AChE) is regulation of cholinergic neurotransmission by hydrolysis of synaptic acetylcholine. In the developing nervous system, however, AChE also functions as a morphogenic factor to promote axonal growth. This raises the question of whether organophosphorus...

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Detalhes bibliográficos
Main Authors: Yang, Dongren, Howard, Angela, Bruun, Donald, Ajua-Alemanj, Mispa, Pickart, Cecile, Lein, Pamela J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2408880/
https://ncbi.nlm.nih.gov/pubmed/18076960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2007.11.005
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