Functional characterization of a U5 ribozyme: intracellular suppression of human immunodeficiency virus type 1 expression.

We have designed a ribozyme that cleaves human immunodeficiency virus type 1 (HIV-1) RNA in U5 (at nucleotide +115). This ribozyme was tested in vitro and was found to give efficient and specific digestion of RNA containing the HIV-1 U5 sequence. When the U5 ribozyme was placed into the HIV-1 genome...

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Bibliografiske detaljer
Udgivet i:J Virol
Main Authors: Dropulić, B, Lin, N H, Martin, M A, Jeang, K T
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1992
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC240867/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1738200/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.66.3.1432-1441.1992
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