In vitro high affinity α-synuclein binding sites for the amyloid imaging agent PIB are not matched by binding to Lewy bodies in postmortem human brain1

Amyloid containing deposits are a defining neuropathological feature of a wide range of dementias and movement disorders. The positron emission tomography tracer PIB (Pittsburgh Compound-B, 2-[4′-(methylamino)phenyl]-6-hydroxybenzothiazole) was developed to target senile plaques, an amyloid containi...

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Detalhes bibliográficos
Main Authors: Ye, Liang, Velasco, Ana, Fraser, Graham, Beach, Thomas G, Sue, Lucia, Osredkar, Tracy, Libri, Vincenzo, Spillantini, Maria Grazia, Goedert, Michel, Lockhart, Andrew
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2008
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2408655/
https://ncbi.nlm.nih.gov/pubmed/18221373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2008.05245.x
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