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Do all of the neurologic diseases in patients with DNA repair gene mutations result from the accumulation of DNA damage?
The classic model for neurodegeneration due to mutations in DNA repair genes holds that DNA damage accumulates in the absence of repair, resulting in the death of neurons. This model was originally put forth to explain the dramatic loss of neurons observed in patients with xeroderma pigmentosum neur...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2008
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2408373/ https://ncbi.nlm.nih.gov/pubmed/18339586 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2008.01.017 |
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