β-Adrenergic regulation requires direct anchoring of PKA to cardiac Ca(V)1.2 channels via a leucine zipper interaction with A kinase-anchoring protein 15

Activation of β-adrenergic receptors and consequent phosphorylation by cAMP-dependent protein kinase A (PKA) greatly increases the L-type Ca(2+) current through Ca(V)1.2 channels in isolated cardiac myocytes. A kinase-anchoring protein 15 (AKAP15) coimmunoprecipitates with Ca(V)1.2 channels isolated...

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izdano v:	Proc Natl Acad Sci U S A
Principais autores:	Hulme, Joanne T., Lin, Teddy W.-C., Westenbroek, Ruth E., Scheuer, Todd, Catterall, William A.
Format:	Artigo
Jezik:	Inglês
Izdano:	National Academy of Sciences 2003
Teme:	Biological Sciences
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC240750/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14569017/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2135335100
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