A presenilin dimer at the core of the γ-secretase enzyme: Insights from parallel analysis of Notch 1 and APP proteolysis

Notch receptors and the amyloid precursor protein are type I membrane proteins that are proteolytically cleaved within their transmembrane domains by a presenilin (PS)-dependent γ-secretase activity. In both proteins, two peptide bonds are hydrolyzed: one near the inner leaflet and the other in the...

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Autors principals: Schroeter, Eric H., Ilagan, Ma. Xenia G., Brunkan, Anne L., Hecimovic, Silva, Li, Yue-ming, Xu, Min, Lewis, Huw D., Saxena, Meera T., De Strooper, Bart, Coonrod, Archie, Tomita, Taisuke, Iwatsubo, Takeshi, Moore, Chad L., Goate, Alison, Wolfe, Michael S., Shearman, Mark, Kopan, Raphael
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2003
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC240747/
https://ncbi.nlm.nih.gov/pubmed/14566063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1735338100
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