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Mutations in human complement regulator, membrane cofactor protein (CD46), predispose to development of familial hemolytic uremic syndrome

Membrane cofactor protein (MCP; CD46) is a widely expressed transmembrane complement regulator. Like factor H it inhibits complement activation by regulating C3b deposition on targets. Factor H mutations occur in 10–20% of patients with hemolytic uremic syndrome (HUS). We hypothesized that MCP mutat...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Richards, Anna, Kemp, Elizabeth J., Liszewski, M. Kathryn, Goodship, Judith A., Lampe, Anne K., Decorte, Ronny, Müslümanogğlu, M. Hamza, Kavukcu, Salih, Filler, Guido, Pirson, Yves, Wen, Leana S., Atkinson, John P., Goodship, Timothy H. J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2003
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC240728/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14566051/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2135497100
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