The development of diabetes in E2f1/E2f2 mutant mice reveals important roles for bone marrow-derived cells in preventing islet cell loss

Our studies of mice deficient for the E2F1 and E2F2 transcription factors have revealed essential roles for these proteins in the cell cycle control of pancreatic exocrine cells and the regulation of pancreatic beta cell maintenance. Pancreatic exocrine cells in E2f1/E2f2 mutant mice become increasi...

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Bibliographic Details
Main Authors: Li, Feng X., Zhu, Jing W., Tessem, Jeffery S., Beilke, Joshua, Varella-Garcia, Marileila, Jensen, Jan, Hogan, Christopher J., DeGregori, James
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2003
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC240722/
https://ncbi.nlm.nih.gov/pubmed/14566047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2231861100
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