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Active sites of thioredoxin reductases: Why selenoproteins?

Selenium, an essential trace element for mammals, is incorporated into a selected class of selenoproteins as selenocysteine. All known isoenzymes of mammalian thioredoxin (Trx) reductases (TrxRs) employ selenium in the C-terminal redox center -Gly-Cys-Sec-Gly-COOH for reduction of Trx and other subs...

Description complète

Enregistré dans:
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Gromer, Stephan, Johansson, Linda, Bauer, Holger, Arscott, L. David, Rauch, Susanne, Ballou, David P., Williams, Charles H., Schirmer, R. Heiner, Arnér, Elias S. J.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2003
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC240667/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14569031/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2134510100
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