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Nitric oxide-donating aspirin inhibits β-catenin/T cell factor (TCF) signaling in SW480 colon cancer cells by disrupting the nuclear β-catenin–TCF association

Dysregulation of the Wnt pathway and altered β-catenin expression are central early events in colorectal carcinogenesis. We studied the ortho, meta, and para (o-, m-, and p-) positional isomers of NO-donating aspirin (NO-ASA), a chemopreventive agent against colon cancer, for their effect on β-caten...

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Bibliografiske detaljer
Main Authors: Nath, Niharika, Kashfi, Khosrow, Chen, Jie, Rigas, Basil
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2003
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC240661/
https://ncbi.nlm.nih.gov/pubmed/14566053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2134840100
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