Non-Syndromic Tooth Agenesis in Two Chinese Families Associated with Novel Missense Mutations in the TNF Domain of EDA (Ectodysplasin A)

Here we report two unrelated Chinese families with congenital missing teeth inherited in an X-linked manner. We mapped the affected locus to chromosome Xp11-Xq21 in one family. In the defined region, both families were found to have novel missense mutations in the ectodysplasin-A (EDA) gene. The mut...

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Detalhes bibliográficos
Main Authors: Li, Shufeng, Li, Jiahuang, Cheng, Jian, Zhou, Bingrong, Tong, Xin, Dong, Xiangbai, Wang, Zixing, Hu, Qingang, Chen, Meng, Hua, Zi-Chun
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2405930/
https://ncbi.nlm.nih.gov/pubmed/18545687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0002396
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