A regulatory variation in OPRK1, the gene encoding the κ-opioid receptor, is associated with alcohol dependence

Variations in OPRK1, which encodes the κ-opioid receptor, are associated with the risk for alcohol dependence. Sequencing DNAs with higher and lower risk haplotypes revealed an insertion/deletion (indel) with a net addition of 830 bp located 1986 bp upstream of the translation start site (1389 bp up...

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Detalhes bibliográficos
Main Authors: Edenberg, Howard J., Wang, Jun, Tian, Huijun, Pochareddy, Sirisha, Xuei, Xiaoling, Wetherill, Leah, Goate, Alison, Hinrichs, Tony, Kuperman, Samuel, Nurnberger, John I., Schuckit, Marc, Tischfield, Jay A., Foroud, Tatiana
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2405904/
https://ncbi.nlm.nih.gov/pubmed/18319328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddn068
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