Replication-defective mutants of herpes simplex virus (HSV) induce cellular immunity and protect against lethal HSV infection.

Live viruses and live virus vaccines induce cellular immunity more readily than do inactivated viruses or purified proteins, but the mechanism by which this process occurs is unknown. A trivial explanation would relate to the ability of live viruses to spread and infect more cells than can inactivat...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Nguyen, L H, Knipe, D M, Finberg, R W
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1992
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC240374/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1331509/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.66.12.7067-7072.1992
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