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Understanding ligand-based modulation of the Hsp90 molecular chaperone dynamics at atomic resolution
Molecular switching and ligand-based modulation of the 90-kDa heat-shock protein (Hsp90) chaperone activity may ultimately facilitate conformational coupling to the ATPase cycle along with activation and recruitment of the broad range of client proteins. We present an atomic resolution analysis of t...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2008
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2402385/ https://ncbi.nlm.nih.gov/pubmed/18511558 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802879105 |
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