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Understanding ligand-based modulation of the Hsp90 molecular chaperone dynamics at atomic resolution

Molecular switching and ligand-based modulation of the 90-kDa heat-shock protein (Hsp90) chaperone activity may ultimately facilitate conformational coupling to the ATPase cycle along with activation and recruitment of the broad range of client proteins. We present an atomic resolution analysis of t...

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Autori principali: Colombo, Giorgio, Morra, Giulia, Meli, Massimiliano, Verkhivker, Gennady
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2402385/
https://ncbi.nlm.nih.gov/pubmed/18511558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802879105
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