Restoration of cell surface CD4 expression in human immunodeficiency virus type 1-infected cells by treatment with a Tat antagonist.

Productive infection of T lymphocytes with human immunodeficiency virus type 1 (HIV-1) is accompanied by a diminution of surface CD4 receptors. Treatment of chronically HIV-1-infected CD4-negative T cells in vitro with the Tat antagonist Ro 5-3335 resulted in a drug dose-dependent decrease in virus...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Shahabuddin, M, Volsky, B, Hsu, M C, Volsky, D J
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1992
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC240182/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1404619/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.66.11.6802-6805.1992
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