Mutations in a herpes simplex virus type 1 origin that inhibit interaction with origin-binding protein also inhibit DNA replication.

The herpes simplex virus type 1 genome contains three origins of replication: OriL and a diploid OriS. The origin-binding protein, the product of the UL9 gene, interacts with two sites within OriS, box I and box II. A third site, box III, which is homologous to boxes I and II, may also be a binding...

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הוצא לאור ב:	J Virol
Principais autores:	Hernandez, T R, Dutch, R E, Lehman, I R, Gustafsson, C, Elias, P
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	American Society for Microbiology (ASM) 1991
נושאים:	Research Article
גישה מקוונת:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC239956/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1847482/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.65.3.1649-1652.1991
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