Tumor Cell Phenotype Is Sustained by Selective MAPK Oxidation in Mitochondria

Mitochondria are major cellular sources of hydrogen peroxide (H(2)O(2)), the production of which is modulated by oxygen availability and the mitochondrial energy state. An increase of steady-state cell H(2)O(2) concentration is able to control the transition from proliferating to quiescent phenotype...

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Main Authors: Galli, Soledad, Antico Arciuch, Valeria Gabriela, Poderoso, Cecilia, Converso, Daniela Paola, Zhou, Qiongqiong, de Kier Joffé, Elisa Bal, Cadenas, Enrique, Boczkowski, Jorge, Carreras, María Cecilia, Poderoso, Juan José
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2008
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2398776/
https://ncbi.nlm.nih.gov/pubmed/18545666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0002379
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