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Removal of LIF (leukemia inhibitory factor) results in increased vitamin A (retinol) metabolism to 4-oxoretinol in embryonic stem cells

Retinoids, vitamin A (retinol) and its metabolic derivatives, are required for normal vertebrate development. In murine embryonic stem (ES) cells, which remain undifferentiated when cultured in the presence of LIF (leukemia inhibitory factor), little metabolism of exogenously added retinol takes pla...

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書誌詳細
主要な著者: Lane, Michelle A., Chen, Anne C., Roman, Shaun D., Derguini, Fadila, Gudas, Lorraine J.
フォーマット: Artigo
言語:Inglês
出版事項: The National Academy of Sciences 1999
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC23981/
https://ncbi.nlm.nih.gov/pubmed/10557354
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