Deficiency of Zonula Occludens-1 Causes Embryonic Lethal Phenotype Associated with Defected Yolk Sac Angiogenesis and Apoptosis of Embryonic Cells

Zonula occludens (ZO)-1/2/3 are the members of the TJ-MAGUK family of membrane-associated guanylate kinases associated with tight junctions. To investigate the role of ZO-1 (encoded by Tjp1) in vivo, ZO-1 knockout (Tjp1(−/−)) mice were generated by gene targeting. Although heterozygous mice showed n...

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Autori principali: Katsuno, Tatsuya, Umeda, Kazuaki, Matsui, Takeshi, Hata, Masaki, Tamura, Atsushi, Itoh, Masahiko, Takeuchi, Kosei, Fujimori, Toshihiko, Nabeshima, Yo-ichi, Noda, Tetsuo, Tsukita, Shoichiro, Tsukita, Sachiko
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Cell Biology 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2397322/
https://ncbi.nlm.nih.gov/pubmed/18353970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E07-12-1215
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