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Place cell firing correlates with memory deficits and amyloid plaque burden in Tg2576 Alzheimer mouse model

Alzheimer's disease (AD) is associated with progressive memory decline. Hippocampal place cells are a well understood candidate for the neural basis of one type of memory in rodents; these cells identify the animal's location in an environment and are crucial for spatial memory and navigat...

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Autors principals: Cacucci, Francesca, Yi, Ming, Wills, Thomas J., Chapman, Paul, O'Keefe, John
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2396558/
https://ncbi.nlm.nih.gov/pubmed/18505838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802908105
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