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Mutagenesis of the Active-Site Cysteine in the Ubiquitin-Specific Protease Contained in Large Tegument Protein pUL36 of Pseudorabies Virus Impairs Viral Replication In Vitro and Neuroinvasion In Vivo

Herpesviruses specify a ubiquitin-specific protease activity located within their largest tegument protein. Although its biological role is still largely unclear, mutation within the active site abolished deubiquitinating (DUB) activity and decreased virus replication in vitro and in vivo. To furthe...

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Hlavní autoři: Böttcher, Sindy, Maresch, Christina, Granzow, Harald, Klupp, Barbara G., Teifke, Jens P., Mettenleiter, Thomas C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2395145/
https://ncbi.nlm.nih.gov/pubmed/18400848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00280-08
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