Genome position and gene amplification

BACKGROUND: Amplifications, regions of focal high-level copy number change, lead to overexpression of oncogenes or drug resistance genes in tumors. Their presence is often associated with poor prognosis; however, the use of amplification as a mechanism for overexpression of a particular gene in tumo...

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Detalhes bibliográficos
Main Authors: Gajduskova, Pavla, Snijders, Antoine M, Kwek, Serena, Roydasgupta, Ritu, Fridlyand, Jane, Tokuyasu, Taku, Pinkel, Daniel, Albertson, Donna G
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2007
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2394771/
https://ncbi.nlm.nih.gov/pubmed/17584934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2007-8-6-r120
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