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NKCC1 and KCC2 Prevent Hyperexcitability in the Mouse Hippocampus

During postnatal development of the central nervous system (CNS), the response of GABA(A) receptors to its agonist undergoes maturation from depolarizing to hyperpolarizing. This switch in polarity is due to the developmental decrease of the intracellular Cl(−) concentration in neurons. Here we show...

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Autors principals: Zhu, Lei, Polley, Nathan, Mathews, Gregory C., Delpire, Eric
Format: Artigo
Idioma:Inglês
Publicat: 2008
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2394664/
https://ncbi.nlm.nih.gov/pubmed/18394864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.eplepsyres.2008.02.005
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