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Monoamine oxidase inhibitors l-deprenyl and clorgyline protect nonmalignant human cells from ionising radiation and chemotherapy toxicity

l-Deprenyl (R-(−)-deprenyl, selegiline) is an inhibitor of monoamine oxidase-B (MAO-B) that is known to protect nerve cells from a variety of chemical and physical insults. As apoptosis is a common mechanism of radiation-induced cell death, the effect of l-deprenyl on the survival of cultured cells...

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Detalhes bibliográficos
Main Authors: Seymour, C B, Mothersill, C, Mooney, R, Moriarty, M, Tipton, K F
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2394440/
https://ncbi.nlm.nih.gov/pubmed/14612913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6601361
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