HIV protease inhibitors provide neuroprotection through inhibition of mitochondrial apoptosis in mice

Neuroprotection can be achieved by preventing apoptotic death of postmitotic cells. Apoptotic death can occur by either a caspase-dependent mechanism, involving cytochrome c, apoptosis protease-activating factor–1 (Apaf-1), and caspase-9, or a caspase-independent mechanism, involving apoptosis-induc...

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Autori principali: Hisatomi, Toshio, Nakazawa, Toru, Noda, Kousuke, Almulki, Lama, Miyahara, Shinsuke, Nakao, Shintaro, Ito, Yasuhiro, She, Haicheng, Kohno, Riichiro, Michaud, Norman, Ishibashi, Tatsuro, Hafezi-Moghadam, Ali, Badley, Andrew D., Kroemer, Guido, Miller, Joan W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2008
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2391064/
https://ncbi.nlm.nih.gov/pubmed/18497877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI34267
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