High pressure fosters protein refolding from aggregates at high concentrations

High hydrostatic pressures (1–2 kbar), combined with low, nondenaturing concentrations of guanidine hydrochloride (GdmHCl) foster disaggregation and refolding of denatured and aggregated human growth hormone and lysozyme, and β-lactamase inclusion bodies. One hundred percent recovery of properly fol...

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Detalles Bibliográficos
Main Authors: St. John, Richard J., Carpenter, John F., Randolph, Theodore W.
Formato: Artigo
Idioma:Inglês
Publicado: The National Academy of Sciences 1999
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC23894/
https://ncbi.nlm.nih.gov/pubmed/10557267
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